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Literature summary extracted from
- Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway (1994), J. Clin. Invest., 93, 1602-1608.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.23.38 | SC-50083 | most selective inhibitor | Plasmodium falciparum |  |
| 3.4.23.39 | Chloroquine-hemin complex | - |
Plasmodium falciparum | |
| 3.4.23.39 | pepstatin | most selective inhibitor | Plasmodium falciparum | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.23.38 | vacuole | - |
Plasmodium falciparum | 5773 | - |
| 3.4.23.39 | vacuole | - |
Plasmodium falciparum | 5773 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.23.38 | Plasmodium falciparum | - |
- |
- |
| 3.4.23.39 | Plasmodium falciparum | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.23.38 | hemoglobin alpha-chain + H2O | cleavage sites: Phe33-/-Leu34, Phe46-/-Asp47, Phe98-/-Lys99 | Plasmodium falciparum | ? | - |
? | |
| 3.4.23.38 | hemoglobin beta-chain + H2O | cleavage sites: Leu31-/-Leu32, Phe41-/-Phe43, Ala129-/-Tyr130 | Plasmodium falciparum | ? | - |
? | |
| 3.4.23.39 | hemoglobin alpha-chain + H2O | cleavage sites: Phe33-/-Leu34, Thr108-/-Leu109, Leu136-/-Thr137 | Plasmodium falciparum | ? | - |
? | |
| 3.4.23.39 | hemoglobin beta-chain + H2O | cleavage site: Leu32-/-Val33 | Plasmodium falciparum | ? | - |
? | |
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